It Came From The Desert DOS 1990 for Windows 7 and above

The 50's "B" movies that inspired a 90's PC Game

That inspired a 2018 movie

It Came From the Desert is an action-adventure game that derives its inspiration from the many cult-horror B-Movies of the 50's and 60's, the 1954 film Them in particular.
Released 1989 for Amiga
Released 1990 for PC DOS
Released as Freeware around 2004
https://www.mobygames.com/game/dos/it-came-from-the-desert
THEM 1954
The earliest atomic tests in New Mexico cause common ants to mutate into giant man-eating monsters that threaten civilization.
https://www.imdb.com/title/tt0047573/
Them! is a 1954 American black-and-white science fiction monster film from Warner Bros. Pictures, produced by David Weisbart, directed by Gordon Douglas, and starring James Whitmore, Edmund Gwenn, Joan Weldon, and James Arness. The film is based on an original story treatment by George Worthing Yates, which was then developed into a screenplay by Ted Sherdeman and Russell Hughes.
Them! is one of the first of the 1950s "nuclear monster" films, and the first "big bug" feature.
A nest of gigantic irradiated ants is discovered in the New Mexico desert; they quickly become a national threat when it is discovered that two young queen ants and their consorts have escaped to establish new nests. The national search that follows finally culminates in a battle with Them in the concrete spillways and storm drain system of Los Angeles.
https://en.wikipedia.org/wiki/Them!_(1954_film)

If you watch the 2018 Movie: "It Came From The Desert"

take note of the reference to "Them!" at about 0:29:50

Growing up in the 50's, we had all the fun of Atom Bombs, Giant Insects, even Robots
http://www.forcesofgeek.com/2013/05/insect-fear-big-bug-movies-of-1950s.html
https://en.wikipedia.org/wiki/I,_Robot